VIP Peptide (Vasoactive Intestinal Peptide)
Introduction
Vasoactive Intestinal Peptide (VIP) is a naturally occurring peptide hormone that plays an important role in cellular signaling and regulatory processes. In research, VIP has been studied extensively for its involvement in vasodilation, neurotransmission, and immune regulation. As a synthetic peptide, VIP is widely used in laboratory settings to explore mechanisms related to receptor binding, signal transduction, and peptide-receptor interactions.
What is VIP?
VIP is a 28-amino acid neuropeptide first identified in the small intestine but later found to be distributed throughout the central and peripheral nervous systems. It belongs to the secretin/glucagon family of peptides and is recognized for its role as a neurotransmitter and neuromodulator in biological systems.
Potential Different Names
-Vasoactive Intestinal Peptide
-VIP
-PHM-27 (Peptide Histidine Methionine, structurally related)
Chemical Formula
C147H237N43O43S
Structure
VIP is a linear peptide chain composed of 28 amino acid residues. Its structure includes hydrophobic and hydrophilic domains that allow it to interact effectively with G-protein-coupled receptors (GPCRs), specifically VPAC1 and VPAC2 receptors. These structural features make VIP a useful subject of study in receptor-ligand interactions and molecular signaling pathways.
How Does It Work?
VIP binds to VPAC1 and VPAC2 receptors, which are part of the GPCR family. Upon binding, it activates adenylate cyclase, leading to an increase in cyclic adenosine monophosphate (cAMP) levels within the cell. This cascade influences multiple intracellular signaling pathways, providing a model system for understanding GPCR function, cAMP signaling, and downstream biological responses.
Conclusion
VIP (Vasoactive Intestinal Peptide) is a well-characterized neuropeptide widely used in research for its ability to activate GPCR pathways and modulate cellular signaling. Its structure and receptor-binding properties make it a valuable tool for studies in molecular biology, pharmacology, and biochemistry.
Disclaimer
This product is intended for research purposes only. It is not intended for human consumption, medical use, or therapeutic applications. VIP should only be handled by qualified professionals in a controlled laboratory environment.