Product Description: IGF-1
Introduction
Insulin-like Growth Factor 1 (IGF-1) is a naturally occurring peptide hormone involved in a variety of biological processes. This protein is closely related to insulin in terms of structure and function and has become a prominent focus of scientific research. IGF-1 is widely used in laboratory settings to study cellular signaling pathways, protein synthesis, and other biochemical processes. Synthetic IGF-1 is often employed to facilitate research, offering consistency and precision in controlled experimental conditions.
What is IGF-1?
IGF-1 is a polypeptide hormone consisting of 70 amino acids. It is primarily produced in the liver in response to signals from growth hormone (GH). It plays a critical role in mediating the effects of growth hormone and is part of the broader IGF axis, which includes IGF-1, IGF-2, and their associated binding proteins. The IGF axis is integral to the regulation of various physiological processes.
Potential Different Names
- Insulin-Like Growth Factor 1
- Somatomedin C
- IGF1
Chemical Formula
C332H514N92O101S7
Structure
The IGF-1 protein is composed of 70 amino acids arranged in a single chain. Its structure includes three disulfide bonds that contribute to its stability and functionality. The molecule shares a high degree of structural similarity with insulin, particularly in its N-terminal and C-terminal domains, which influence its receptor-binding activity.
How Does It Work?
IGF-1 operates by binding to the Insulin-like Growth Factor 1 Receptor (IGF1R), a tyrosine kinase receptor expressed on the surface of many cell types. Upon binding, IGF-1 induces receptor autophosphorylation, which activates intracellular signaling cascades. Key pathways associated with IGF-1 activity include:
- PI3K-Akt Pathway: Involved in regulating cell survival, metabolism, and growth.
- MAPK Pathway: Linked to cell differentiation and proliferation.
IGF-1’s interaction with its receptor triggers a sequence of intracellular events that researchers can study to understand protein synthesis, gene expression, and the regulation of metabolic activities. In addition to IGF1R, IGF-1 can interact with binding proteins that modulate its availability and activity in different experimental contexts.
Conclusion
IGF-1 is a vital component of peptide research due to its role in cellular signaling and regulatory mechanisms. By using synthetic IGF-1 in laboratory experiments, researchers can delve into its structural and functional properties, contributing to a deeper understanding of molecular pathways.
Disclaimer
IGF-1 is intended for research purposes only and is not approved for diagnostic, therapeutic, or clinical applications. This description is provided solely for informational purposes and does not constitute medical advice. Proper handling, storage, and adherence to regulatory guidelines are essential for its use in laboratory settings.